Yes, but if You install it as a package You could access to the configuration script which is useful at installing/removing DXVK in Wine prefixes and developing with vkd3d, apart from the other packaging advantages.
I don't really see a reason, and it would in fact be problematic to do so, given:
- The primary usecase for this is playing known supported / working titles via Steam Proton and applications like Lutris.
- Newer releases of DXVK, included the latest release, frequently bump Vulkan requirements, meaning DXVK will constantly be moved from a functional to non-functional state as Vulkan progresses and newer features are not supported on older graphics cards. As a result, any usage of this in a system-wide context can break at any time for the user, whereas a more controlled mechanism like Lutris or Steam Proton ensures your game targets a specific DXVK release and is easier to roll back to an older version that supports your GPU.