There are many applications and games which currently don't work with vanilla wine, but work with wine staging. Seeing through history build I saw that wine used to be build with staging patches, but no more since you consider it pretty unstable. However, other distributions offer wine staging either by default (Fedora), or as a 2nd package (arch) or with external sources (Ubuntu) since too many people need it in order to get their software working.
I've created a personal repository for Solus which has wine built with staging patches: https://github.com/ThanosApostolou/solus-wine-staging-repository since I need it to get some applications working.
My proposal is this:
Make a pinned task (it could be this one) with a list of applications and games which don't work with wine, but they are tested and known to work with wine staging. Then try to find the minimum amount of wine staging patches which are required in order to get these applications work and apply them to the official wine build (it's not easily done and it requires a lot of community involvement). Would you be interested in this even if it means delay wine builds until the required patches are ready? The list could be something like that:
- League of Legends
REST SOFTARE: (maybe some office)