See screenshot from GNOME Screenshot uploaded here: https://i.postimg.cc/tgWx2DjT/Screenshot-from-2022-05-19-09-18-57.png
Only the upper left quadrant of the screen is captured, the rest is left black. I'm not sure when this regressed, but it didn't happen before.
Using Solus Budgie, packages fully updated.
My screen resolution is 3840 x 2160 (16:9) with 200% UI scaling.
$ gnome-screenshot --version gnome-screenshot 41.0